Genome instability: a conserved mechanism of ageing?
نویسندگان
چکیده
منابع مشابه
Genome instability of ageing stem cells—Induction and defence mechanisms
The mammalian organism is comprised of tissue types with varying degrees of self-renewal and regenerative capacity. In most organs self-renewing tissue-specific stem and progenitor cells contribute to organ maintenance, and it is vital to maintain a functional stem cell pool to preserve organ homeostasis. Various conditions like tissue injury, stress responses, and regeneration challenge the st...
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DNA single-strand breaks (SSBs) are the commonest DNA lesions arising spontaneously in cells, and if not repaired may block transcription or may be converted into potentially lethal/clastogenic DNA double-strand breaks (DSBs). Recently, evidence has emerged that defects in the rapid repair of SSBs preferentially impact the nervous system. In particular, spinocerebellar ataxia with axonal neurop...
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ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2017
ISSN: 0071-1365,1744-1358
DOI: 10.1042/ebc20160082